On this question I solved the problem of querying Google Datastore to retrieve stuff by user (com.google.appengine.api.users.User) like this:
User user = userSer
Using string substitution in query languages is always a bad idea. It's far too easy for a user to break out and mess with your environment, and it introduces a whole collection of encoding issues, etc.
What was wrong with your earlier parameter substitution approach? As far as I'm aware, it supports everything, and it sidesteps any parsing issues. As far as the problem with knowing how many arguments to pass goes, you can use Query.executeWithMap or Query.executeWithArray to execute a query with an unknown number of arguments.