According to this
http://perldoc.perl.org/UNIVERSAL.html
I shouldn\'t use UNIVERSAL::isa() and should instead use $obj->isa() or CLASS->isa().
This means
Assuming your example of what you want to be able to do is within an object method, you're being unnecessarily paranoid. The first passed item will always be either a reference to an object of the appropriate class (or a subclass) or it will be the name of the class (or a subclass). It will never be a reference of any other type, unless the method has been deliberately called as a function. You can, therefore, safely just use ref to distinguish between the two cases.
if (ref $_[0]) {
my $self = shift;
# called on instance, so do instancey things
} else {
my $class = shift;
# called as a class/static method, so do classy things
}