A thief can always turn back the clock to within 14 days of the install, as well as virtualization to achieve the same end. Can you count on net access and have the program phone home for a key?
HASP is one company that does this full time.
Also, depending on factors such as the size of your target market, your purchase price, your competition, and the ecosystem you're selling to, you might consider that some amount of priracy might be your best marketing tool. Which is the greater risk: that your software is widely pirated, or that your software is lost in the noise and few ever even try it? Some software allegedly owes it success to wide spread piracy (WordStar, dBase, Lotus 1-2-3, iirc). A quick google shows that Chapter 13 of "in search of stupidity" touches on this.
It's a tough question, good luck.