That is evil!
If the interviewer asks an NP-complete question in an interviewer the only response they can reasonably expect is that the interviewee respond with a proof that the problem is NP-complete. In a low-stress environment like a university homework question, this usually takes a bright student 2-3 or more hours to prove. The proof itself can take several pages to write out completely, perhaps several hours of work itself. In a high-stress environment like an interview you can expect that the interviewee may not even recognize that this is np-complete.
The only reasonable alternative is that the interviewee produce an approximation algorithm; however, in this case the interviewer should make it explicitly clear that they are fine with approximations.
Even so, most approximations only come with an order of 2 of the correct answer.
I guess there is 1 more alternative: the interviewee suggests that a search-type algorithm maybe the most suitable (take for example the integer-domain optimization problem which is NP-complete, most approximation algorithms use a branch and bound search spin on the simplex algorithm to produce decent results.)