I\'m going to give an example of using System.Data.SQLite.DLL which is a mixed assembly with unmanaged code: If I execute this :
var assembly= Assembly.LoadF
The problem is that the CLR does not perform the normal DLL loading steps - like mapping the dlls separate sections into different pages, adjusting fixups, etc. When an assembly is loaded from raw bytes, those raw bytes are mapped into memory as is, and only managed meta-data is read. No amount of evidence or security settings will change this behavior.
We are the victim of a crummy exception message. Loading assemblies with Assembly.Load(byte[]) that contain unmanaged code is not supported. This is the subject of this feedback item.
UPDATE: the linked feedback item is gone, deleted as part of the cleanup at VS2012 release time. The only part of it could still recover is this fragment, copied from another web page:
“[…] we only allow ILOnly images to be loaded […] since anything else is not safe”--
UPDATE: link fixed with archive.org backup copy.