Quickest way to clear all sheet contents VBA

Question

I have a large sheet that I need to delete all the contents of. When I try to simply clear it without VBA it goes into not responding mode. When using a macro such as:

Answer 1

Technically, and from Comintern's accepted workaround, I believe you actually want to Delete all the Cells in the Sheet. Which removes Formatting (See footnote for exceptions), etc. as well as the Cells Contents. I.e. Sheets("Zeroes").Cells.Delete

Combined also with UsedRange, ScreenUpdating and Calculation skipping it should be nearly intantaneous:

Sub DeleteCells ()
    Application.Calculation = XlManual
    Application.ScreenUpdating = False
    Sheets("Zeroes").UsedRange.Delete
    Application.ScreenUpdating = True
    Application.Calculation = xlAutomatic
End Sub

Or if you prefer to respect the Calculation State Excel is currently in:

Sub DeleteCells ()
    Dim SaveCalcState
    SaveCalcState = Application.Calculation
    Application.Calculation = XlManual
    Application.ScreenUpdating = False
    Sheets("Zeroes").UsedRange.Delete
    Application.ScreenUpdating = True
    Application.Calculation = SaveCalcState
End Sub

Footnote: If formatting was applied for an Entire Column, then it is not deleted. This includes Font Colour, Fill Colour and Borders, the Format Category (like General, Date, Text, Etc.) and perhaps other properties too, but

Conditional formatting IS deleted, as is Entire Row formatting.

(Entire Column formatting is quite useful if you are importing raw data repeatedly to a sheet as it will conform to the Formats originally applied if a simple Paste-Values-Only type import is done.)