According to this question:
Displaying PDF documents on iPad - Color Problems
some PDFs don\'t display right on iOS devices due to colors not being in RGB. It\'s
On mac, you could use sips command. For example,
sips --matchTo '/System/Library/ColorSync/Profiles/Generic RGB Profile.icc' CMYKinput.pdf --out RGBoutput.pdf
And RGB pdf can be converted into CMYK in the same way (change 'Generic RGB Profile.icc' to 'Generic CMYK Profile.icc').
Tested on OSX 10.12.