I'm using Doctrine in a medium sized project where I had to work from pre-existing databases I don't own. It gives you alot of built in features, but I have one major complaint.
Since I had to generate my models from the databases and not vice-versa, my models are too close to the database: the fields have very similar names to the database columns, to get objects you have to query in what is essential sql (where do I put that code, and how do I test it?), etc.
In the end I had to write a complex wrapper for doctrine that makes me question if it wouldn't have been easier to just use the old dao/model approach and leave doctrine out of the picture. The jury is still out on that. Good luck!