I have the following error in the Chrome Dev Tools console on every page-load of my Node/Express/React application:
Unchecked runtime.lastError: Could not es
For me this was caused by :
Iobit Surfing Protection & Ads Removal extension
which comes with Iobit advanced system care software. However, the console might provide you with relevant information on what you need do disable or the cause for that problem.
The likely cause of this error, as per google searches is because that extension which causes the error, might be using the chrome.runtime.sendMessage() and then tries to use the response callback.
Error shown in the console
Hope this information helps. Have a great day!