A number of applications have the handy feature of allowing users to respond to notification emails from the application. The responses are slurped back into the application.>
EDIT: I misunderstood your question.
You could configure your email server to catch-all, and generate a unique reply-to address. E.g. CST-2343434@example.com.
A polling process on the server could read the inbox and parse out the relevant part from the received email, CS-2343434 could mean Customer Support ticket ID no. 2343434.
I implemented something like this using JavaMail API.
Just a thought.