I am using Thinktecture AuthorizationServer (AS) and it is working great.
I would like to write a native javascript single page app which can call a WebAPI directly, how
Sounds like you need to queue requests in the event that an access token expires. This is more or less how Facebook and Google do it. A simple way using Angular would be to add a HTTP Interceptor and check for HTTP401 responses. If one is returned, you re-authenticate and queue any requests that come in after until the authentication request has completed (i.e. a promise). Once that's done, you can then process the outstanding queue with the newly returned access token from your authentication request using your refresh token.
Happy Coding.