The main calling card of both Lisp and Prolog in this particular field is that they support metaprogramming concepts like lambdas. The reason that is important is that it helps when you want to roll your own programming language within a programming language, like you will commonly want to do for writing expert system rules.
To do this well in a lower-level imperative language like C, it is generally best to just create a separate compiler or language library for your new (expert system rule) language, so you can write your rules in the new language and your actions in C. This is the principle behind things like CLIPS.
