We are about to embark on a large enterprise application. I am seriously considering using ASP.NET MVC because:
I would say go with MVC if you need or want its features . If you are building a line-of-business application such as an ERP or CRM system, I would use Webforms; if you are building a portal or community wiki type site I would go with MVC hands down. Ultimately it comes down to preference and what exactly your enterprise application needs to accomplish.