I have published my website on Amazon EC2 (Singapore region) and I have used MySQL RDS instance for the data storage. Everything is working very fine except performance.
Always should deploy source and rds in the same AWS availability zone for lower network latency and Should create a private endpoint link in VPC for RDS to connect RDS endpoint through the internal network instead of routing through the internet.
Reference: https://docs.aws.amazon.com/AmazonRDS/latest/UserGuide/vpc-interface-endpoints.html