With the new HTTP/2 protocol the overhead created by repeated HTTP requests to the same server has been greatly reduced.
With this in mind, are there still any significa
Yes, it is still useful.
Along-side with gzip compression, you page will weight less.
Imagine you are using a very slow GPRS (56Kbps, 500ms ping) network.
You have 50 tiny images, 30 javascripts and 20 css files.
This means that, with 2 parallel connections, you must wait over 100 * 500ms just for the requests.
Now, each image is about 3-4kb. Which might take a few milliseconds (5-8?).
Now, the CSS files and Javascript range from 20Kb to 600Kb.
This will kill your website with a huge transfer time.
Reducing the time to transfers the files will increase the 'speed' at which the website will load.
So, YES, it is still useful!