\"Fluent interfaces\" is a fairly hot topic these days. C# 3.0 has some nice features (particularly extension methods) that help you make them.
FYI, a fluent API means
This is actually the first time I've heard the term "fluent interface." But the two examples that come to mind are LINQ and immutable collections.
Under the covers LINQ is a series of methods, most of which are extension methods, which take at least one IEnumerable and return another IEnumerable. This allows for very powerful method chaining
var query = someCollection.Where(x => !x.IsBad).Select(x => x.Property1);
Immutable types, and more specifically collections have a very similar pattern. Immutable Collections return a new collection for what would be normally a mutating operation. So building up a collection often turns into a series of chained method calls.
var array = ImmutableCollection.Empty.Add(42).Add(13).Add(12);