Here is a similar question at answers.semanticweb.com: Python OWL2 API
which references this one: Is there a tool for reading functional owl syntax in Python?
. Answers to both of them mention InfixOWL which is a part of FuXi.
FuXi does not support RDFLib 3, but there is a ticket as well as some active effort for making that happen. If you wish to use FuXi right away, you can always switch from RDFLib to layercake ("an RDFLib fork readily compatible with FuXi").