Error:
Could not open the editor: The editor class could not be instantiated. This
at org.eclipse.core.runtime.Path.(Path.java:183)
at org.eclipse.core.internal.resources.WorkspaceRoot.getProject(WorkspaceRoot.java:181)
at org.eclipse.jdt.internal.core.ExternalFoldersManager.isExternalFolderPath(ExternalFoldersManager.java:90)
at org.eclipse.jdt.internal.core.JavaProject.addToResult(JavaProject.java:2738)
at org.eclipse.jdt.internal.core.JavaProject.resolveClasspath(JavaProject.java:2688)
The stack trace seem to indicate that there is a problem with your classpath.
Edit: Another Idea ... launch eclipse on an other workspace. Then create a launch configuration for an "Eclipse Configuration" with the workspace that produces an error. Set a java exception breakpoint for NullPointerException. Start in debug mode and you can inspect the variables to see which path produces the problems.