As far as the weirdest thing I've seen squeezed into Access...
I am a police dispatcher for a smaller university, and we (like almost every agency) use a CAD (computer aided dispatch) and RMS (record management system) system.
Our previous CAD/RMS software was built ENTIRELY into Access. You opened Access, and through an ugly GUI, entered calls for service, everything. Officers wrote reports through the same interface.
It worked great at first, and then as the database size grew, it became extremely slow and difficult to use. This is what happens when the state makes you go with the lowest bidder on a project...
Now we use a CAD/RMS solution that is browser-based, backed by MS SQL.