I have a 150MB one-sheet excel file that takes about 7 minutes to open on a very powerful machine using the following:
# using python import xlrd wb = xlrd.open_
I would like to have more info about the system where you are opening the file... anyway:
look in your system for a Windows update called "Office File Validation Add-In for Office ..."
if you have it... uninstall it... the file should load much more quickly specially if is loaded froma share