In Visual Studio 2008, \'Start Debugging\' switches Visual Studio to a different layout. How can I force Visual Studio to use a single layout at all times?
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Many people try to turn of this feature because of strange behaviors (glitches) off VS windows on multi-monitor configurations.
In such cases there is other option that can help: Turn off Environment->General->"Optimize rendering for screens with different pixels densities"
https://developercommunity.visualstudio.com/content/problem/830128/windows-layout-not-restoring-properly-in-multi-mon.html