While starting to use Sass / Compass with Django couldn\'t be much easier regardless of platform, it has taken a bit of searching around to find the best way to use CoffeeScript
You can use one of these CoffeeScript compilers.
Some of them support file system watching, like the official node package. So you can start a console and do
coffee -c src/ -o /bin --watch
and all the coffeescript files in src will be automatically recompiled when they change. You don't need any special integration with django, although it might be nice.