No need to list anymore "Cons" - but here is a significant "Pro" - Filemaker Go. Once you have your database setup, download a ipad/iphone app (free for FM12) and run it from a mobile device. The database can be stored locally on the ipad/iphone or synced back to a host PC.
I'm sure this mobile solution is possible elsewhere - but the fundamental point is that an entry-level user (and I mean NO previous database experience) can create an impressive solution within a few weeks.
Personal experience: main database running FM 11 hosted on PC under my desk - 4 researchers scattered across the city collecting data on ipads - all syncing back to my PC. Previous solution was using paper and entering in data by hand.
