Since the vast majority of monitors are 16-bit color or more, including mobile devices, does it make sense to even consider web-safe colors when choosing color schemes? Or is i
It depends what you mean by web safe colours.
In terms of 16bit colour it's probably not worth worrying about. However Colours do not appear the same across devices. This can lead to all sorts of problems particularly if a designers gamma settings are different to your particular monitor set up.
So you still need to test your design across multiple set ups.