Are web-safe colors still relevant?

Question

Since the vast majority of monitors are 16-bit color or more, including mobile devices, does it make sense to even consider web-safe colors when choosing color schemes? Or is i

Answer 1

For those of us (like me) that didn't know exactly what web safe colors are, they were

developed at a time when many computer displays were only capable of displaying 256 colors. A set of colors was needed that could be shown without dithering on 256-color displays; the number 216 was chosen partly because computer operating systems customarily reserved sixteen to twenty colors for their own use; it was also selected because it allows exactly six shades each of red, green, and blue (6 × 6 × 6 = 216).

The list of colors is often presented as if it has special properties that render them immune to dithering. In fact, on 256-color displays applications can set a palette of any selection of colors that they choose, dithering the rest. These colors were chosen specifically because they matched the palettes selected by the then leading browser applications.

It's hard to imagine any of this applying to today's modern displays, since almost nobody runs their display in 256 colors anymore (unless perhaps they are playing an old version of Leisure Suit Larry).