Since the vast majority of monitors are 16-bit color or more, including mobile devices, does it make sense to even consider web-safe colors when choosing color schemes? Or is i
I think the most important thing when choosing a colour palette is keeping in mind colour-blindness. There are a few different types that I know of, but the main thing is making sure that you have enough contrast between colours.
For example green text on a red background might be easier for some to read, but very difficult or maybe impossible for others (5-10% of males!), especially if the values of the colours are close.