Are web-safe colors still relevant?

Question

Since the vast majority of monitors are 16-bit color or more, including mobile devices, does it make sense to even consider web-safe colors when choosing color schemes? Or is i

Answer 1

For me web safe color palette is no longer primary concern. Optimize for the largest target audience.

According to w3schools site visitors:

• In January 2009 1% of site visitors had 256 color displays, 95% of users had 24 or 32 bit.
• [Update] In January 2015 0.5% had 256 colours, 0.5% had 24 bit and 99% had 32 bit

I found similar numbers from a business app site that I look after:

32-bit  79.01%  

24-bit  15.64%  

16-bit  5.27%   

8-bit   0.08%