Like, Control-A (select all) followed by delete?
Select all in Emacs is:
C-x h
(technically, that's mark-whole-buffer) and kill-region (to kill the marked region, which is now the entire buffer) is:
C-w
If you want to delete the region without copying it to the kill-ring, you can use
M-x delete-region
instead. If you do this alot, you'll want to bind delete-region to a key/key combo.