Split each PDF page in two?

Question

I have a large number of PDF files which have two slides to a page (for printing).

The format is A4 pages each with two slides setup like so:

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Answer 1

Try BRISS.

It lets you split each page into as many subpages as you want by defining regions with a GUI. It groups all similar pages into groups for you, so you can define regions for that group once.

It's cross-platform, free, and open-source.

(copy-pasted from https://superuser.com/a/235327/35237)