I think the best option is to divide css in:
-layout.css
-content.css
Then if you need other more specific you can add more like an css for the ads: ads.css, or one css for a specific section.
I would also add ie.css for IE css hacks.
I would not speak about creating one css for only one page: the problem you can have if you use too many css, is that your page will have to do more requests to the server and this will slow your page.
This is why i recommend you to implement an HttpHandler which will create a cache copy in only one file of the css you need at the moment. Look here:
http://blog.madskristensen.dk/post/Combine-multiple-stylesheets-at-runtime.aspx