Pinterest & Instagram use django, i'm sure it's scaleable, for most loaded parts such as activities feed you can use in-memory storage like Redis.
high-load sites on django
Disqus
http://www.slideshare.net/zeeg/djangocon-2010-scaling-disqus
Pinterest
http://www.slideshare.net/eonarts/mysql-meetup-july2012scalingpinterest
Instagram
http://instagram-engineering.tumblr.com/