YUI Compressor was the consensus best tool for minimizing, but Closure seems like it could be better.
I think it depends on your code. If you want to compile your own code, then I think it is worth it to patch the code so that it works with Closure Compiler (some things might seem a bit awkward at the start). I believe Closure Compiler soon will be the top choice for such jobs and it will also make you to tidy up your code a bit and maintain consistent style (of course it depends on your preferences, you might hate some parts, I do :P ).
If you depend on other libraries then in my opinion you should wait a bit until they release Closure Compiler compatible versions. It shouldn't take much time for most popular libraries out there. And maybe you can provide fixes for those "not-so-active" libraries which you use yourself.
I'm talking about Advanced Compilation mode here, the Simple Compilation mode as some has pointed out is fairly safe to use.
And here's a different opinion - Google Closure ? I'm Not Impressed. It's maybe a little bit too harsh, but nice read. I guess only time will tell which one is better =)