Every time I start a project with some graphical toolkit, one of the first conflicts happen with the decision of how to deal with the visual design and the widget layout: A grap
My answer is based on two years developing biochemistry applications using PyQt4 (Python bindings to Qt 4) and OpenGL. I have not done C++ Qt, because we only used C++ for performance-critical algorithms. That said, the PyQt4 API greatly resembles Qt4, so much here still applies.
Qt Designer
Hand coding
Good
Bad
Tips
Don't just jump into creating your windows. Start by quickly sketching several possible designs, either on paper or using a tool like Balsamiq Mockups. Though you could do this in Qt Designer, I think it is too tempting to spend a lot of time trying to get your windows to look just right before you've even decided if it is the best design.
If you use Qt Designer for PyQt, you have the extra step of running pyuic4 to compile your *.ui files to Python source files. I found it easy to forget this step and scratch my head for a second why my changes didn't work.
If you code your UI by hand, I suggest putting your layout code in one place and your signals and slots in another place. Doing this makes it easier to change the way your widgets are arranged on a window without affecting any of your application logic. Or you can change some behavior without having to wade through all the layout code.
Enjoy Qt! Now that I am using Java Swing for work, I miss it.