Have you considered Smalltalk? It offers a very simple, clear and extensible syntax with reflectivity and introspection capabilities and a fully integrated development environment that takes advantage of those capabilities. Have a look at some of the work being done in Squeak Smalltalk for instance. A lot of researchers using Squeak hang out on the Squeak mailing list and #squeak on freenode, so you can get help on complex issues very easily.
Other indicators of its current relevance: it runs on any platform you'd care to name (including the iPhone); Gilad Bracha is basing his Newspeak work on Squeak; the V8 team cut their teeth on Smalltalk VMs; and Dan Ingalls and Randal Schwartz have recently returned to Smalltalk work after years in the wilderness.
Best of luck with your search - let us know what you decide in the end.
