Short answer:
- almost anything you can do with macros you can do with a higher-order function (and I include monads, arrows, etc.), but it might require more thinking (but only the first time, and it's fun and you'll be a better programmer for it), and
- the static system is sufficiently general that it never gets in your way, and somewhat surprisingly it actually "aids in achieving agility" (as you said) because when your program compiles you can be almost certain that is correct, so this certainty lets you try out things you might be otherwise afraid to try -- there is a "dynamic" feel to programming although it's not the same as with Lisp.
[Note: There is a "Template Haskell" that lets you write macros just as in Lisp, but strictly speaking you should never need it.]
