In Chrome for desktop I have options in the dev tools to disable cache completely when dev tools are opened and I have the options to manually do a hard reload when long clickin
EDIT: This method has been deprecated in Google Chrome and will no longer work.
ORIGINAL ANSWER:
I was able to clear the cache (including subsequent xhr) using chrome://net-internals
Then click the little arrow in the top right
Select "clear cache" from that menu.