Subtract one dataframe from another excluding the first column Pandas

Question

I have to dataframes with the same columns. My task should be to subtract the df_tot from df_nap without touching the first column (\'A\'). What is the easiest solution for it?<

Answer 1

you can also use join and iloc:

df_tot.iloc[:,:1].join(df_tot.iloc[:,1:]-df_nap.iloc[:,1:])

but this implies to have the same order of columns and 'wavelength' being the first one