I would proboby use the SelectedIndexChanged event on the first dropdownlist. Like this:
ASPX
VB
Private Sub ddl1_SelectedIndexChanged(ByVal sender As Object, ByVal e As System.EventArgs) Handles ddl1.SelectedIndexChanged
If ddl1.SelectedValue = "1" Then
ddl2.SelectedValue = "C"
End If
End Sub