Yep, I want it to work like in Flask framework - there I could set parameters like this:
static_folder=os.getcwd()+\"/static/\", static_url_path=\"\"
I believe this is not supported out of the box. Off the top of my head, one way to do it would be with a special 404 handler that, having failed to match against any of the defined URLs, treats the request as a request for a static resource. This would be reasonably easy to do in the development environment but significantly more difficult when nginx, Apache, and/or gunicorn get involved.
In other words, don't do this. Nest your statics (or put them on a different sub domain) but don't mix the URL hierarchy in this way.