I am playing with generating dot files and then turned them into SVG graphs with a lot of nodes.
My question is that are there event listeners to detect mouse clicks on
Just another thought on this (realizing the question is old, but maybe it helps someone coming across).
Depending on what you want to do, it may be easiest to decouple the event handling from the drawing. I mean, you can find out where graphviz positions the nodes (as well as edges, labels etc.), see, for example, this post on how to do it in python. Then you can paint the graph in the background of whatever GUI you're using, and use its native event handling to react on on_click
by placing invisible clickable objects over the nodes.