Why is IIS Express returning HTTP 500 errors loading javascript and CSS?

Question

I am trying to develop an ASP.NET MVC5 solution using IIS Express for local debugging. Frequently, Chrome will report HTTP500 errors trying to load certain JS and CSS files (so

Answer 1

In my case, I got to remove the attribute of debug="true" in web.config compilation node.

From

To

Then it works fine.