Why is IIS Express returning HTTP 500 errors loading javascript and CSS?

Question

I am trying to develop an ASP.NET MVC5 solution using IIS Express for local debugging. Frequently, Chrome will report HTTP500 errors trying to load certain JS and CSS files (so

Answer 1

Turns out this was related to ninject object lifecycles and my EF db context being open twice at the same time. Totally unrelated to IIS.