One more... perhaps unoptimized way would be to decompose the matrix into cells row-wise, transpose the cell array then concatenate everything back together:
B = cell2mat(mat2cell(A, size(A, 1), 4 * ones((size(A, 2) / 4), 1)).');
The above first uses mat2cell to decompose the matrix into non-overlapping cells. Each cell has the same number of rows as A but the total number of columns is 4 and there are exactly size(A, 2) / 4 of them. As such, we need to indicate a vector of ones where each element is 4 and there are size(A, 2) / 4 of these to tell us the number of columns for each cell. This creates a row-wise cell array and so we transpose this cell array and merge all of the cells together into one final matrix with cell2mat.
