I am using resharper to do a big refactoring and i keep going from file to file and adding the same namespace over and over again in the \"using\" section
When you encounter a file, one-by-one, press CTRL+ALT+SHIFT+F for the automated file cleanup routine. It just takes a second to run, and will do what you're looking for, but not just for System.
not sure if R# has a way to do solution wide file cleanups.