I want to create several files from a single template, which differ only by a variable name. For example :
(file1.rst):
.. |variable| replace:: 1
..
There are two problems here: a substitution problem, and a parsing order problem.
For the first problem, the substitution reference |variable|
cannot have adjacent characters (besides whitespace or maybe _ for hyperlinking) or else it won't parse as a substitution reference, so you need to escape it:
./images/\ |variable|\ -image.png
However, the second problem is waiting around the corner. While I'm not certain of the details, it seems reST is unable to parse substitutions inside other directives. I think it first parses the image directive, which puts it in the document tree and thus out of reach of the substitution mechanism. Similarly, I don't think it's possible to use a substitution to insert content intended to be parsed (e.g. .. |img1| replace::`.. image:: images/1-image.png`
). This is all speculative based on some tests and my incomplete comprehension of the official documentation, so someone more knowledgeable can correct what I've said here.
I think you're aware of the actual image substitution directive (as opposed to text substitution), but I don't think it attains the generality you're aiming for (you'll still need a separate directive for the image as from the |variable|), but in any case it looks like this:
.. |img1| image:: images/1-image.png
Since you're using Sphinx, you can try creating your own directive extension (see this answer for information), but it won't solve the substitutions-inside-markup problem.