I have never really found the design view in Visual Studio useful when developing aspx pages, and so I basically never use it.
Am I missing something or is it just o
It's useful only if you are trying to generate your button click events the quick way, your page-lifecycle events the easy way, or to set up your demoware controls (like the gridview, the datasources, etc).
Other than that, leave it be.
Even when you do want to use it, use split view if possible (like in 2008), as it prevents Microsoft form 'improving' your formatting for you.