I have two dataframes:
df1= A B C 0 A0 B0 C0 1 A1 B1 C1 2 A2 B2 C2 df2= A B C 0 A2 B2 C10 1 A1 B3 C11 2 A9 B4
~df1['A'].isin(df2['A'])
Should get you the series you want
df1[ ~df1['A'].isin(df2['A'])]
The dataframe:
A B C 0 A0 B0 C0