Currently I am working on a MFC application which reads and writes in to the disk. Sometimes this application runs amazingly fast and sometimes it is damn slow. I am guessin
Try to batch up your writes to disk to avoid many small calls to write. When you're done flushing your buffer, call commit. commit (aka fsync) is an expensive operation, so becomes even more so when there are lots of small writes.
On windows file handles you can experiment with FILE FLAG WRITE THROUGH to increase write speeds. Supposedly commit doesn't have to be called with handles using this flag.
If data you are writing to disk will also be accessed through reading, consider writing to an in memory structure first, having another thread read from the structure to write it to disk. This will help avoid calls to read data from disk that you have just written.