RxJava noClassDefFoundError: rx.plugins.RxJavaPlugins on API 16

Question

I am developing an Android application using RxJava and Retofit. When I test my code on API 23 I get no errors however when I test in API 15, my RxJava doesnt appear to work

Answer 1

Thanks for bikash, his top solution really works.Yet in my program, my Application class has extended another ***Application. I finally solve this by overriding attachBaseContext(Context base) function in my application class to initial MultiDex. In a word, I do like this:

defaultConfig {//first step
        multiDexEnabled true
    }

dependencies {compile 'com.android.support:multidex:1.0.1'}//second

 @Override
protected void attachBaseContext(Context base) {
    super.attachBaseContext(base);
    MultiDex.install(this);//finally
}

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