I have a DataFrame in this format:
a b c
0 1 2 3
1 4 5 6
2 7 8 9
3 10 11 12
4 13 14 15
and an array like
For large datasets, you can use indexing on the base numpy data, if you're prepared to transform your column names into a numerical index (simple in this case):
df.values[arange(5),[0,0,1,2,1]]
out: array([ 1, 4, 8, 12, 14])
This will be much more efficient that list comprehensions, or other explicit iterations.